Table 2.
Univariate and multivariate Cox proportional hazards regression analyses for the association between AST/ALT (DeRitis) ratio and incident diabetes in different models.
| Variables | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| AST/ALT | 0.32 (0.29, 0.36) | < 0.001 | 0.32 (0.28, 0.37) | < 0.001 | 0.49 (0.41, 0.59) | < 0.001 | 0.56 (0.37, 0.85) | 0.006 |
| P for trend | < 0.001 | < 0.001 | < 0.001 | a | ||||
| Q1 | 3.54 (3.05, 4.10) | < 0.001 | 3.13 (2.66, 3.68) | < 0.001 | 1.82 (1.49, 2.23) | < 0.001 | ||
| Q2 | 2.33 (2.00, 2.72) | < 0.001 | 1.85 (1.58, 2.17) | < 0.001 | 1.27 (1.05, 1.54) | 0.012 | ||
| Q3 | 1.37 (1.15, 1.62) | < 0.001 | 1.18 (1.00, 1.41) | 0.055 | 0.85 (0.70, 1.05) | 0.133 | ||
| Q4 | Ref | Ref | Ref | |||||
Model 1 was adjusted for age, gender, BMI and family history of diabetes. Model 2 was further adjusted for SBP, DBP, FPG, Cholesterol, Triglyceride, HDL-C, LDL-C, BUN and CCR on the basis of model 1. Model 3 was further adjusted for smoking status and drinking status on the basis of model 2.
Represents P value > 0.05 and AST/ALT (DeRitis) ratio was not included in the final fitting model. ALT, alanine aminotransferase; AST, aspartate transaminase; BMI, body mass index; BUN, blood urea nitrogen; CCR, endogenous creatinine clearance rate; CI, confidence interval; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure.