Table 3.
Association between AST/ALT (DeRitis) ratio and incident diabetes based on restricted cubic spline regressions.
| Variables | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| AST/ALT ≤ 1.18 | 0.27 (0.21, 0.36) | < 0.001 | 0.17 (0.13, 0.23) | < 0.001 | 0.21 (0.15, 0.32) | < 0.001 | 0.42 (0.19, 0.91) | 0.028 |
| AST/ALT > 1.18 | 0.67 (0.52, 0.86) | 0.002 | 0.76 (0.59, 0.97) | 0.025 | a | a | ||
Model 1 was adjusted for age, gender, BMI and family history of diabetes. Model 2 was further adjusted for SBP, DBP, FPG, Cholesterol, Triglyceride, HDL-C, LDL-C, BUN and CCR on the basis of model 1. Model 3 was further adjusted for smoking status and drinking status on the basis of model 2.
Represents P value > 0.05 and AST/ALT (DeRitis) ratio was not included in the final fitting model. ALT, alanine aminotransferase; AST, aspartate transaminase; BMI, body mass index; BUN, blood urea nitrogen; CCR, endogenous creatinine clearance rate; CI, confidence interval; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure.