Table 2.
Univariate and multivariate cox analyses of inflammatory indicators in the COVID-19 Omicron BA.2 infected patients.
| Model 0 | Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|---|
| cases/controls | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | |
| dNLR | |||||||
| Per SD (increased) | 1.404 (1.292-1.526) | <0.001 | 1.220 (1.089-1.367) | 0.001 | 1.237 (1.098-1.393) | <0.001 | |
| < 4.01 | 28/2078 | Ref | Ref | Ref | |||
| ≥ 4.01 | 29/212 | 8.780 (5.220-14.767) | <0.001 | 4.191 (2.383-7.371) | <0.001 | 4.272 (2.417-7.552) | <0.001 |
| NLR | |||||||
| Per SD (increased) | 1.206 (1.138-1.278) | <0.001 | 1.271 (1.150-1.405) | <0.001 | 1.281 (1.164-1.410) | <0.001 | |
| < 5.73 | 25/1995 | Ref | Ref | Ref | |||
| ≥ 5.73 | 32/295 | 7.587 (4.493-12.812) | <0.001 | 3.351 (1.909-5.879) | <0.001 | 3.571 (1.998-6.188) | <0.001 |
| SII | |||||||
| Per SD (increased) | 1.247 (1.167-1.333) | <0.001 | 1.255 (1.114-1.413) | <0.001 | 1.279 (1.138-1.438) | <0.001 | |
| < 999 | 23/1937 | Ref | Ref | Ref | |||
| ≥ 999 | 34/353 | 7.756 (4.567-13.171) | <0.001 | 3.703 (2.105-6.514) | <0.001 | 4.591 (2.595-8.120) | <0.001 |
| SIRI | |||||||
| Per SD (increased) | 1.154 (1.075-1.237) | <0.001 | 1.186 (1.044-1.347) | 0.009 | 1.193 (1.005-1.348) | 0.005 | |
| < 3.77 | 36/2069 | Ref | Ref | Ref | |||
| ≥ 3.77 | 21/221 | 4.909 (2.865-8.413) | <0.001 | 2.493 (1.402-4.436) | 0.002 | 2.680 (1.497-4.798) | 0.001 |
| PLR | |||||||
| Per SD (increased) | 1.338 (1.207-1.483) | <0.001 | 1.152 (1.031-1.287) | 0.012 | 1.181 (1.045-1.334) | 0.008 | |
| < 275 | 35/2065 | Ref | Ref | Ref | |||
| ≥ 275 | 22/225 | 5.317 (3.118-9.067) | <0.001 | 3.187 (1.826-5.561) | <0.001 | 3.412 (1.936-6.012) | <0.001 |
| MLR | |||||||
| Per SD (increased) | 1.222 (1.093-1.367) | <0.001 | 1.121 (0.963-1.307) | 0.142 | 1.132 (0.973-1.316) | 0.108 | |
| < 0.75 | 41/2064 | Ref | Ref | Ref | |||
| ≥ 0.75 | 16/226 | 2.926 (1.639-5.220) | <0.001 | 1.890 (1.050-3.401) | 0.034 | 1.968 (1.090-3.553) | 0.025 |
Cox proportional hazard models were used. Model 0, unadjusted model; Model 1, adjusted by age, gender, disease severity; Model 2, adjusted by Model 1, hypertension, diabetes, heart disease, kidney disease, lung disease, brain disease and malignant tumors. CI, confidence interval; HR, hazard ratio; SD, standard deviation; Ref, reference; dNLR, derived neutrophil to lymphocyte ratio; NLR, neutrophil to lymphocyte ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index; PLR, platelet to lymphocyte ratio; MLR, monocyte to lymphocyte ratio.