TABLE 6.
Highlights current clinical trials of the use of MSCs in cell therapy applications.
| Clinical trial identifier | iPSCs source | Title | Objective | Phase | Status | Trial duration | Country |
|---|---|---|---|---|---|---|---|
| NCT03883750 | Induced pluripotent stem cells | Induced pluripotent stem cells in Niemann Pick Disease (IPSNPABC) | Generate patient-specific induced pluripotent stem cells and then differentiate them into neural cells to study misfolded proteins in the endoplasmic reticulum, their role in the response of untranslated proteins, and possible mechanisms to shuttle misfolded proteins into lysosomes | N/A | Completed | 19 June 2018–1 December 2019 | Pakistan |
| NCT03872713 | Induced pluripotent stem cells | Establishment of Human Cellular Disease Models for Morquio Disease (IPSMORQUIO) | To prepare a cell culture from patients affected with Morquio disease to identify novel pathways and proteins involved in disease progression that allow for an earlier diagnosis | N/A | Completed | 26 October 2018–01 December 2019 | Pakistan |
| NCT03867526 | Induced pluripotent stem cells | Establishment of Human Cellular Disease Models for Wilson Disease (IPSWILSON) | Create a human cellular model for addressing hepatic and neurologic forms of the disease | N/A | Completed | 19 June 2018–01 December 2019 | Pakistan |
| NCT02923375 | Induced pluripotent stem cells | A Study of CYP-001 for the Treatment of Steroid-Resistant Acute Graft Versus Host Disease | To assess the safety, tolerability, and efficacy of two CYP-001 infusions in adults with steroid-resistant GvHD. | Phase 1 | Completed | 01 March 2017–28 August 2018 | Australia, United Kingdom |
| NCT01534624 | Induced pluripotent stem cells | Stem Cell Study of Genetics and Drug Addiction | To study genetic and cell differences between people who are addicted to drugs and those who are not | N/A | Completed | 07 February 2012–30 July 2014 | United States |
| NCT03372746 | Induced pluripotent stem cells | Generation of Induced Pluripotent Stem Cell Lines (iPS) from Skin Fibroblast Cells of Participants with Age-Related Macular Degeneration | Establish a bank of samples that can be changed into other cell types, such as eye cells, to better understand diseases such as AMD, and to test drugs in order to treat various eye diseases | N/A | Completed | 23 Ma y 2018–21 March 2019 | United State |