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. 2022 Nov 16;19:57. doi: 10.1186/s12979-022-00310-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Supercentenarians present higher titers of IgG to RBDs of seasonal coronaviruses than for SARS-CoV-2 and neutralization titers above 160 (the minimum titer initially established by the FDA for convalescent plasma donors) [35]. The numbers represent the 3 individuals. The graph on top indicates IgG ratios for each RBD and the table above shows VNT for SARS-COV-2. VNT - Virus Neutralization Titers. Antibody levels expressed in ratios are shown for SARS-CoV-2 and the four seasonal coronaviruses. Neutralization titers are expressed in dilution. ID 02 was asymptomatic, and IDs 1 and 3 were symptomatic and recovered from Covid-19