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. 2022 Nov 16;19:57. doi: 10.1186/s12979-022-00310-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Plasma proteomics and metabolomics analyses of the supercentenarians infected with SARS-CoV-2 compared to healthy elderly subjects (> 95 years-old / non-infected). Volcano plots showing differentially expressed proteins (A) and metabolites (B). Red and blue dots represent the up- and down-regulated proteins/metabolites, respectively. Protein-metabolite interaction network was built with the statistically significant proteins with OmicsAnalyst platform (C). Red and blue nodes denote the up- and down-regulated proteins/metabolites, respectively. Circle and diamond node shapes represent metabolites and proteins, respectively