Table 1.
Baseline characteristics of all enrolled subjects.
| Parameter | HC (N = 47) | CHB (N = 68) | HBV-related cirrhosis (HBV-LC) | p value | |
|---|---|---|---|---|---|
| NO LF (N = 94) | LF (N = 73) | ||||
| BMI | 22.19 (19.2–23.7) | 22.8 (19.8–25.5) | 23.1 (20.8–25.1) | 22.2 (20.3–24.0) | 0.439 |
| Age (years) | 32 (28–36) | 34 (26–38) | 49 (43–55) * | 48 (42–54) * | <0.001 |
| Male (N, %) | 21 (44.7) | 55 (80.9) * | 67 (71.3) * | 55 (75.3) * | 0.376 |
| HE (N, %) | 0 | 0 | 1 (1.1) | 4 (5.5) | |
| Ascites (N,%) | 0 | 3 (4.4) | 35 (37.2) | 48 (65.8) | <0.001 |
| Bacterial infection (N, %) | 0 | 9 (13.2) | 39 (41.5) | 51 (69.9) | <0.001 |
| GI bleeding (N, %) | 0 | 0 | 8 (8.5) | 7 (9.6) | |
| Laboratory data | |||||
| PLT (*10^9/L) | 205 (160–227) | 179 (129–216)* | 77 (50–108)* | 54 (36–85)* | <0.001 |
| TBil (mg/dl) | 0.5 (0.2–0.7) | 1.2 (0.7–3.3)* | 1.3 (0.7–2.6)* | 5.2 (1.6–13.8)* | <0.001 |
| ALT (U/L) | 19 (12–24) | 136 (58–289)* | 32 (21–78)* | 41 (21–109)* | <0.001 |
| AST (U/L) | 18 (14–22) | 57 (36–107)* | 41 (28–81)* | 57 (36–131)* | 0.08 |
| Albumin (g/L) | 47.1 (44.7–49.1) | 38.9 (35.2–42.1)* | 34.2 (30.5–38.3)* | 30.1 (21.7–31.7)* | <0.001 |
| HBV-DNA (log IU/ml) | 2.0 (0–5.5) | 2.0 (0.0–5.5) | 3.1 (0–5.1) | <0.001 | |
| INR | 1.1 (1.0–1.1) | 1.3 (1.1–1.4) | 1.9 (1.7–2.2) | <0.001 | |
| PTA | 89 (79–101) | 71 (61–81) | 42 (35–49) | <0.001 | |
| Cr (mg/dl) | 0.7 (0.6–0.9) | 0.8 (0.6–0.8) | 0.8 (0.7–0.9) | 0.7 (0.6–0.8) | 0.026 |
| Serum sodium (mmol/L) | 138.6 (137.1–139.7) | 137.9 (135.6–139.2) | 135.3 (132.5–137.9) | <0.001 | |
Data are expressed as median (interquartile range) or count (percentage), Statistical analysis was calculated using the man-whitney U test between two groups and the Kruskal-Wallis test among three groups. p value shows the difference among the HC group, HBV-LC (NO LF) group and HBV-LC (LF) group. p < 0.05 is considered significantly statistical difference. HC: healthy controls; CHB: chronic hepatitis B; HBV-LC (NO LF): HBV-related cirrhosis without liver failure; HBV-LC (LF): HBV-related cirrhosis with liver failure; BMI: body mass index; HE: hepatic encephalopathy; GI bleeding: gastrointestinal bleeding; PLT: platelets; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBil: total bilirubin; INR: international normalized ratio; PTA: prothrombin activity; Cr: creatinine.
p < 0.05 compared with HC group.