Table 4.
Reproductive outcomes of IVF cycles in women with single APA vs. both APA antibodies in women with tubal etiology infertility.
IVF laboratory outcomes and pregnancy outcomes | Single antibody-positive (n=36) | Both antibody-positive (n=8) | p-value |
---|---|---|---|
Days of ovarian stimulation | 11.0 ± 3.7 | 11.1 ± 2.4 | 0.928 |
Total Gn dose (IU) | 2151.2 ± 1045.0 | 2437.5 ± 868.4 | 0.480 |
Retrieved oocytes | 10.4 ± 6.3 | 9.7 ± 3.0 | 0.676 |
M II oocytes rate (%) | 71.9 ± 19.1 | 53.9 ± 32.0 | 0.139 |
Normal fertilization rate (%) | 59.6 ± 25.3 | 43.3 ± 32.2 | 0.105 |
Embryos | 6.6 ± 3.7 | 5.7 ± 3.9 | 0.583 |
Perfect embryos | 2.4 ± 2.3 | 1.5 ± 1.4 | 0.336 |
Available embryos | 3.4 ± 3.3 | 3.0 ± 2.7 | 0.802 |
Blastocyst formation rate (%) | 21.4 ± 20.6 | 16.0 ± 20.5 | 0.537 |
Perfect embryo rate (%) | 33.9 ± 24.4 | 23.9 ± 22.5 | 0.354 |
Available embryo rate (%) Clinical pregnancy rate (%) Implantation rate (%) Miscarriage rate (%) Take-home baby rate (%) |
48.8 ± 33.1 20.4 (11/54) 13.3 (11/83) 25.9 (14/54) 11.1 (6/54) |
41.2 ± 41.7 13.3 (2/15) 8.7 (2/23) 40 (6/15) 6.7 (1/15) |
0.592 0.808 0.818 0.459 0.983 |
APA, antiphospholipid antibody, such as anti-cardiolipin antibody and/or β2-glycoprotein-I antibody; Clinical pregnancy rate, the number of clinical pregnancy cycles / the total cycles; Implantation rate, the number of gestational sacs / the number of embryos transferred; Miscarriage rate, the number of miscarriage cycles / the total cycles; Take-home baby rate, the number of take-home baby cycles / the total cycles.