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. 2022 Nov 2;13:986893. doi: 10.3389/fimmu.2022.986893

Table 4.

Reproductive outcomes of IVF cycles in women with single APA vs. both APA antibodies in women with tubal etiology infertility.

IVF laboratory outcomes and pregnancy outcomes Single antibody-positive (n=36) Both antibody-positive (n=8) p-value
Days of ovarian stimulation 11.0 ± 3.7 11.1 ± 2.4 0.928
Total Gn dose (IU) 2151.2 ± 1045.0 2437.5 ± 868.4 0.480
Retrieved oocytes 10.4 ± 6.3 9.7 ± 3.0 0.676
M II oocytes rate (%) 71.9 ± 19.1 53.9 ± 32.0 0.139
Normal fertilization rate (%) 59.6 ± 25.3 43.3 ± 32.2 0.105
Embryos 6.6 ± 3.7 5.7 ± 3.9 0.583
Perfect embryos 2.4 ± 2.3 1.5 ± 1.4 0.336
Available embryos 3.4 ± 3.3 3.0 ± 2.7 0.802
Blastocyst formation rate (%) 21.4 ± 20.6 16.0 ± 20.5 0.537
Perfect embryo rate (%) 33.9 ± 24.4 23.9 ± 22.5 0.354
Available embryo rate (%)
Clinical pregnancy rate (%)
Implantation rate (%)
Miscarriage rate (%)
Take-home baby rate (%)
48.8 ± 33.1
20.4 (11/54)
13.3 (11/83)
25.9 (14/54)
11.1 (6/54)
41.2 ± 41.7
13.3 (2/15)
8.7 (2/23)
40 (6/15)
6.7 (1/15)
0.592
0.808
0.818
0.459
0.983

APA, antiphospholipid antibody, such as anti-cardiolipin antibody and/or β2-glycoprotein-I antibody; Clinical pregnancy rate, the number of clinical pregnancy cycles / the total cycles; Implantation rate, the number of gestational sacs / the number of embryos transferred; Miscarriage rate, the number of miscarriage cycles / the total cycles; Take-home baby rate, the number of take-home baby cycles / the total cycles.