TABLE 1.

The effect of TCM injections exposure on ATP depletion in HepG2 cells.

TCM injection	IC50-ATP	IC50-ATP	IC50-ATP	IC50-ATP	Mitochondrial toxicity
	Mean ± SD	Mean ± SD	Glu/Gal	Dose	Glu/Gal ≥ 2
	Glucose	Galactose	Ratio	Unit	Yes/No
Xiyanping	1541.9000	276.9333	5.5678	μg/ml	Yes
Dengzhanhuasu	323.6333	151.3333	2.1385	μg/ml	Yes
Shuanghuanglian	385.0000	191.4900	2.1796	μg/ml	Yes
Yinzhihuang	0.0124	0.0059	2.1061	ml/ml	Yes
Salvianolate	215.6000	136.4000	1.5806	μg/ml	No
Sodium aescinate	24.8200	18.5200	1.3402	μg/ml	No
Shuganning	0.0106	0.0083	1.2809	ml/ml	No
Xueshuantong	>1/100	>1/100	N/A	ml/ml	N/A
Huangqi	>1/100	>1/100	N/A	ml/ml	N/A
Reduning	>1/100	>1/100	N/A	ml/ml	N/A
Yadanziyouru	>1/100	>1/100	N/A	ml/ml	N/A
Xingnao	>1/100	>1/100	N/A	ml/ml	N/A
Danhong	>1/100	>1/100	N/A	ml/ml	N/A
Shenfu	>1/100	>1/100	N/A	ml/ml	N/A
Shenmai	>1/100	>1/100	N/A	ml/ml	N/A
Shuxuening	>100	>100	N/A	μg/ml	N/A
Yimucao	>1/100	>1/100	N/A	ml/ml	N/A
Chaihu	>1/100	>1/100	N/A	ml/ml	N/A
Lianbizhi	>100	>100	N/A	μg/ml	N/A
Shuxuetong	>1/100	>1/100	N/A	ml/ml	N/A
Ginkgo biloba extract	>100	>100	N/A	μg/ml	N/A
Tanreqing	>1/100	>1/100	N/A	ml/ml	N/A
Kushen	>1/100	>1/100	N/A	ml/ml	N/A
Shenkang	>1/100	>1/100	N/A	ml/ml	N/A
Shengmai	>1/100	>1/100	N/A	ml/ml	N/A
Kanglaite	>100	>100	N/A	μg/ml	N/A
Danshen	>100	>100	N/A	μg/ml	N/A
Yanhuning	>100	>100	N/A	μg/ml	N/A
Phloroglucinol-1	>100	>100	N/A	μg/ml	N/A
Phloroglucinol-2	>100	>100	N/A	μg/ml	N/A
Gastrodin	>100	>100	N/A	μg/ml	N/A
Yiqifumai	>100	>100	N/A	μg/ml	N/A
Astragalus polysacharin	>100	>100	N/A	μg/ml	N/A
Aidi	>1/100	>1/100	N/A	ml/ml	N/A
Shenqifuzheng	>1/100	>1/100	N/A	ml/ml	N/A

IC₅₀ ATP-Glu/Gal≥2 indicates potential mitochondrial toxicity; N/A represents Non-applicable.