TABLE 4.

The toxicity reports of the ingredients from TCM injections.

Compound	Toxicity reports	References
Baicalin	1) Body as a whole-general disorders	Cai et al. (2017), Deng et al. (2017), Gao et al. (2014), Shii et al. (2020), Wang et al. (2020), Zhang et al. (2017), Zhang et al. (2012), Zhang et al. (2021d), Zhang et al. (2021c), Zhao et al. (2021b)
	2) Liver dysfunction (liver fibrosis)
	3) Kidney dysfunction (renal fibrosis)
	4) Other impairments (interstitial pneumonia, exert weak decomposition toxicity, Embryo toxicity)
Rutin	1) Body as a whole-general disorders (anaphylactoid reaction; headache, rashes, muscle stiffness)	Sanz-Serrano et al. (2021), Wilson (2017), Zhang et al. (2017), Zhao et al. (2021b)
	2) Cardiovascular disorders (slow or fast heartbeat)
	3) Nervous system disorder (blurred vision, nervousness)
	4) Other impairments (genotoxicity, producing frameshift mutations)
Phillyrin	1) Low probability of genetic toxicitylow sub-chronic toxicity	Han et al. (2021), Han et al. (2017)
Scutellarin	1) No adverse reactions have been reported	Melamed-Gal et al. (2018), Wu et al. (2021), Zhao et al. (2021b)