TABLE 5.
The effect of ingredients from TCM injections exposure on ATP depletion in HepG2 cells.
| Compound | IC50-ATP | IC50-ATP | IC50-ATP | IC50-ATP | Mitochondrial toxicity |
|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Glu/Gal | Dose | Glu/Gal ≥ 2 | |
| Glucose | Galactose | Ratio | Unit | Yes/No | |
| Rutin | 549.4000 | 256.6000 | 2.1411 | μM | Yes |
| Baicalin | 1203.5000 | 432.4000 | 2.7833 | μM | Yes |
| Scutellarin | 521.7000 | 252.2000 | 2.0686 | μM | Yes |
| Phillyrin | 3757.0000 | 769.2000 | 4.8843 | μM | Yes |
| Andrographolide | 53.9500 | 41.2433 | 1.3081 | μM | No |
IC50 ATP-Glu/Gal≥2 indicates potential mitochondrial toxicity.