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. 2022 Nov 2;13:977569. doi: 10.3389/fphys.2022.977569

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Copyright © 2022 Varga, Whitaker-Fornek, Maletz and Levitt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microinjections of OX2R agonists into the KF transiently slowed breathing in anesthetized adult mice. Respiration was monitored with induction plethysmography. In this representative example trace (A) Orexin B peptide was injected into the KF in the left hemisphere in multiple consecutive injections (three 50 nl and two 100 nl Orexin B peptide injections) in a continuous experiment. Orexin B peptide injections led to volume-dependent reductions in respiratory rate (bottom trace; rate measured in breaths per minute [bpm]). Representative example traces of breathing immediately before and after 100 nl microinjections of either vehicle (B), MDK 5220 (C), or Orexin B peptide (D) into the KF.