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. 2022 Oct 18;298(12):102615. doi: 10.1016/j.jbc.2022.102615

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

PNP controls NR metabolism in mammals. A, after being imported into cells by members of the ENT family, NR is intensively metabolized by PNP-dependent cleavage to Nam which is then released from cells. B, suppression of PNP activity by Immucillin H (ImmH) blocks NR conversion to Nam and thereby redirects NR toward NAD⁺ synthesis via NRK and NMNAT activities. ENTs, equilibrative nucleoside transporters; Nam, nicotinamide; NAMPT, Nam phosphoribosyltransferase; NMN, Nam mononucleotide; NMNAT, NMN adenylyltransferase; NR, nicotinamide riboside; NRK, NR kinase; PNP, purine nucleoside phosphorylase.