Figure 1. Adjusted Hazard Ratios (HRs) for Ischemic Heart Disease and Stroke From Flexible Parametric Survival Models.

Hazard ratios (orange lines) and 95% CIs (gray lines) for ischemic heart disease (A) and stroke (B) in offspring according to maternal preeclampsia. A spline with 5 degrees of freedom (4 intermediate knots and 2 knots at each boundary, placed at quintiles of the distribution of events) was used for the baseline rate, and a spline with 3 degrees of freedom was used for the time-varying effect. Analyses were adjusted for offspring calendar year of birth; offspring sex; and maternal parity, age, educational level, marital status, and diabetes status before childbirth.