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Genetic characteristics of familial hyperaldosteronism
| Familial hyperaldosteronism | Gene | Clinical manifestations |
|---|---|---|
| Type I | CYP11B1/CYP11B2 chimeric gene | Glucocorticoid-suppressive hyperaldosteronism |
| Type II | CLCN2 | Early-onset PA |
| Type III | KCNJ5 | Two types: Mild PA (G151E, Y152C) Severe early-onset PA (T158A, I157S, E145Q, G151R) |
| Type IV | CACNA1H | Early-onset PA |
PA, primary aldosteronism
