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. Author manuscript; available in PMC: 2022 Nov 16.
Published in final edited form as: Biochem Pharmacol. 2020 Oct 28;183:114305. doi: 10.1016/j.bcp.2020.114305

Figure 1: Regulation of serum Pi levels.

Figure 1:

In response to a high Pi diet serum Pi levels increase along with FGF23, expressed in osteoblasts and osteocytes, while PTH is increased in the parathyroid gland. Both proteins act on receptors in the kidney to reduce the number of Pi-transporters thereby increasing Pi excretion and lowering serum Pi levels. Simultaneously, the synthesis of vitamin D3 is decreased in the kidney which is thought to decrease Pi absorption in the gut and to generate a negative feedback loop to decrease synthesis and release of PTH and FGF23.