Table 4.
Parameter | Unit | Enpp1wt + PBS | ENPP1asj/asj + PBS | Enpp1asj/asj + BL-1118 |
---|---|---|---|---|
| ||||
Calcium | mg/dL | 6.6 ± 0.5 | 7.0 ± 0.8 | 6.9 ± 0.4 |
Phosphate | mg/dL | 6.4 ± 0.9 | 5.7 ± 0.5 | 5.5 ± 0.8 |
PTH | pg/mL | 137 ± 80 | 229 ± 89 | 524 ± 248*(↑) |
FGF23 | pg/mL | 172 ± 28 | 439 ± 215*(↑) | 614 ± 167***(↑) |
PPi | nM | 2235 ± 621 | 51 ± 22**** (↓) | 1358 ± 268**(↓) |
FGF3 =fibroblastic growth factor 23; PPi = pyrophosphate; PTH = parathyroid hormone.
Text in bold represents abnormal values.
p < 0.05,
p < 0.01,
p < 0.001,
p < 0.0001.