FIGURE 4.

Curcumin and DMC inhibit the activity of HKMTs targeting H3K27. HL60 leukaemia cells were treated with different concentrations of curcumin or DMC (A and B, respectively) and U937 cells were treated with curcumin or DMC (C and D, respectively) followed by measuring the activity of the HKMTs that methylates H3K27. The enzymatic activity was calculated as described under methods. Data represent the mean of three replicates ± SD. * and brackets indicate significant difference from the compared concentration at p < .05 using one‐way anova post hoc Bonferroni test