FIGURE 5.

Curcumin and DMC increase the activity of the histone lysine demethylases LSD1 and JARID. HL60 leukaemia cells were treated with different concentrations of curcumin or DMC followed by measuring the activity of LSD1 (A and B, respectively) or JARID (C and D, respectively). The enzymatic activity was calculated as described under methods. Data represent the mean of three replicates ± SD. * and brackets indicate significant difference from the compared concentration at p < .05 using one‐way anova post hoc Bonferroni test