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. 2022 Nov 1;26(22):5565–5579. doi: 10.1111/jcmm.17529

FIGURE 2.

FIGURE 2

Effect of ferroptotic cancer cells in the tumor microenvironment. Ferroptotic cancer cells can affect immune cells in the tumor microenvironment in many ways to promote or inhibit the antitumor immune response. Various damage‐associated molecular patterns (DAMPs) produced by ferroptotic cancer cells can promote the differentiation and maturation of T cells and dendritic cells to enhance their immune functions. In addition, 1‐steaoryl‐2‐15‐HpETE‐sn‐glycero‐3‐phosphatidylethanolamine (SAPE‐OOH) on the surface can promote the phagocytosis of macrophages through toll‐like receptor 2 (TLR2). Conversely, ferroptotic cancer cells can secrete a large amount of KRASG12D, which promotes the polarization of M1 macrophages into M2 macrophages and damages their ability to kill tumor cells.