FIGURE 3.

Roles of ferroptosis in antitumor therapy. Three common antitumor treatment methods—chemotherapy, radiotherapy, and immunotherapy—have played important roles in antitumor treatment. However, when they face tumor resistance, radiotherapy resistance, and immunosuppression, they are often ineffective. Ferroptosis has introduced some new methods. These three common treatment methods can promote the ferroptosis of tumor cells together with ferroptosis inducers. Conversely, ferroptosis inducers can enhance these three treatments by reversing tumor resistance, radiotherapy resistance, and immunosuppression.