Table 1. Affinities of Psilocybin Analogues in Radioligand Binding Assays for Human 5-HT Receptors^a.

	5-HT1A	5-HT1B	5-HT1D	5-ht1e	5-HT2A	5-HT2B	5-HT2C	5-HT5A	5-HT6	5-HT7a
Drug	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)	Ki (nM)
norpsilocin	86	99	194	161	391	57	243	365	54	68
baeocystin		370	394	1,352		134				117
4-AcO-NMT	141	994	150	522	1,512	76	729	389	82	1,766
psilocin	164	580	130	155	180	8	175	116	38	75
psilocybin	5,284	4,983	186	601		259	808		89	138
psilacetin	337	1,178	108	335	395	9	210	350	112	157
4-HO-TMT						720			2,267
aeruginascin
4-AcO-TMT						891
DOI			607	713	11	5	41		2,254	1,857

^aRadioligands used, reference control compound used, and control K_i values for each 5-HT receptor were 5-HT_1A = [³H]WAY100635 vs. 8-HO-DPAT (K_i = 0.6 nM), 5-HT_1B = [³H]GR125743 vs. ergotamine tartrate (K_i = 4 nM), 5-HT_1D = [³H]GR125743 vs. ergotamine tartrate (K_i = 4 nM), 5-ht_1e = [³H]5-HT vs. 5-HT (K_i = 2 nM), 5-HT_2A = [³H]ketanserin vs. clozapine (K_i = 4 nM), 5-HT_2B = [³H]LSD vs. SB206553 (K_i = 18 nM), 5-HT_2C = [³H]mesulergine vs. ritanserin (K_i = 1 nM), 5-HT_5A = [³H]LSD vs. ergotamine tartrate (K_i = 12 nM), 5-HT₆ = [³H]LSD vs. clozapine (K_i = 7 nM), 5-HT_7a = [³H]LSD vs. clozapine (K_i = 20 nM). No value = <50% inhibition of radioligand binding in the 10 μM primary screening. DOI = (±)-2,5-dimethoxy-4-iodoamphetamine.