Table 3. Affinity of Psilocybin Analogues at 5-HT1A Receptors in Mouse Braina.
| ligand | affinity—mouse brain |
|---|---|
| [3H]8-OH-DPAT binding m5-HT1A | |
| Ki (nM) | |
| norpsilocin | 29 |
| (22–39) | |
| baeocystin | 25 |
| (21–29) | |
| 4-AcO-NMT | 50 |
| (39–65) | |
| psilocin | 118 |
| (84–165) | |
| psilocybin | 197 |
| (118–328) | |
| psilacetin | 299 |
| (205–438) | |
| 4-HO-TMT | >10,000 |
| aeruginascin | >10,000 |
| 4-AcO-TMT | >10,000 |
a
Reference compounds WAY100635 and 5-HT displayed affinities of 4.4 (3.3–5.8) nM and 3.2 (2.4–4.1) nM, respectively. Affinity values are accompanied by 95% CI in parentheses below.