Table 2. Kinome Selectivity of JS25.

kinase	IC50 (M)ab	selectivity (kinase/BTK)
BTK	2.85 × 10–8 ± 0.55	1
BMX	4.90 × 10–8 ± 0.40	1.7
TXK	1.90 × 10–7 ± 0.50	6.7
TEC	2.20 × 10–7 ± 0.30	7.7
ITK	4.40 × 10–7 ± 0.10	15.4
BLK	2.60 × 10–6 ± n.d.	104
EGFR	>3 × 10–6	n.d.
ERBB2	>3 × 10–6	n.d.
JAK3	>3 × 10–6	n.d.

^aAverage of duplicates, showing mean ± S.D.

^bn.d.: not determined.