Table 1.
Comparison among malaria testing methods
| Enrollment (n = 240) |
Follow-up (n = 120) |
All samples (n = 360) |
|
|---|---|---|---|
| qPCR positive, n (%) | 156 (65.0%) | 64 (53.3%) | 220 (61.1%) |
| qPCR density median [IQR] (calculated pRBCs/μL) | 19.5 [1.5, 281.1] | 13.3 [1.6, 164.4] | 17.1 [1.5, 248.9] |
| Microscopy positive, n (%) | 92 (38.3%) | 24 (20.0%) | 116 (32.2%) |
| us-RDT positive, n (%) | 108 (45%) | 45 (37.5%) | 153 (42.5%) |
| Micro sensitivity (%) [95%CI] | 53.8 [50.3, 57.3] | 35.9 [26.4, 45.4] | 48.6 [46.9, 50.3] |
| us-RDT sensitivity (%) [95%CI] | 60.3 [54.6, 66.0] | 50.0 [ 50.0, 50.0] | 57.3 [53.4, 61.2] |
| Micro specificity (%) [95%CI] | 90.5 [79.1, 100] | 98.2 [80.6, 100] | 93.6 [84.0, 100] |
| us-RDT specificity (%) [95%CI] | 83.3 [73.0, 93.6] | 76.8 [63.7, 89.9] | 80.7 [72.6, 88.8] |
| Micro PPV (%) [95%CI] | 91.3 [79.8, 100] | 95.8 [78.7, 100] | 92.2 [82.7, 100] |
| us-RDT PPV (%) [95%CI] | 87.0 [76.1, 97.9] | 71.1 [ 59.6, 82.7] | 82.4 [74.1, 90.1] |
| Micro NPV (%) [95%CI] | 51.4 [49.3, 53.5] | 57.3 [ 50.4, 64.1] | 53.7 [50.9, 56.5] |
| us-RDT NPV (%)[ 95%CI] | 53.0 [49.9, 56.1] | 57.3 [50.4, 64.1] | 54.6 [51.5, 57.7] |