Table 3.

Risk factors of development of carotid plaque during 3-year follow-up

Variables	Univariate models		Multivariate models
	HR (95%CI)	P value	HR (95%CI)	P value
Gender (male)	1.327 (1.095–1.608)	0.004	1.327 (1.068–1.650)	0.011
Age (years)	1.052 (1.042–1.062)	< 0.001	1.049 (1.039–1.060)	< 0.001
SBP (mmHg)	1.014 (1.009–1.020)	< 0.001	1.004 (0.997–1.012)	0.246
LDL-C (mmol/L)	1.072 (0.946–1.215)	0.275	1.054 (0.917–1.212)	0.456
HDL-C (mmol/L)	0.681 (0.496–0.933)	0.017	0.880 (0.585–1.324)	0.539
History of hyperlipidemia	1.376 (0.959–1.975)	0.083	1.073 (0.737–1.561)	0.713
History of hypertension	1.490 (1.226–1.811)	< 0.001	1.057 (0.811–1.377)	0.682
History of diabetes	2.207 (1.643–2.966)	< 0.001	0.717 (0.519–0.991)	0.044
BMI Classification
Underweight (< 18.5)	Ref.	0.558	Ref.	0.144
Normal (18.6–24.9)	1.551 (0.690–3.484)	0.288	1.207 (0.532–2.741)	0.653
Overweight (25–29.9)	1.651 (0.730–3.734)	0.228	0.932 (0.401–2.166)	0.869
Obesity (> = 30)	1.831 (0.735–4.56)	0.194	1.003 (0.388–2.595)	0.995
TyG
Quartile 1	Ref.	< 0.001	Ref.	0.044
Quartile 2	1.590 (1.194–2.116)	0.001	1.376 (1.021–1.854)	0.036
Quartile 3	1.423 (1.059–1.912)	0.019	1.083 (0.779–1.507)	0.634
Quartile 4	2.026 (1.535–2.675)	< 0.001	1.437 (1.007–2.052)	0.046

Bold P values indicate significance

SBP systolic blood pressure, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, BMI body mass index