Table 5.

Univariate and multivariate regression analysis of overall survival (OS) in patients with pancreatic signet ring cell carcinoma (PSRCC)

Variables	Levels	Univariate	Multivariate
		HR (95% CI)	P-value	HR (95% CI)	P-value
Age at diagnosis	<=67	1		1
	> 67	1.27 (1.07–1.50)	0.005	1.22 (0.87–1.71)	0.244
Sex	Female	1
	Male	1 (0.84–1.18)	0.982	/	/
Race	Black
	Other	1.15 (0.76–1.73)	0.507	/	/
	White	0.93 (0.71–1.23)	0.616	/	/
Year of diagnosis	2000–2009	1		1
	2010–2018	0.80 (0.67–0.95)	0.009	0.71 (0.50–1.00)	0.052
Marital status at diagnosis	Married	1		1
	Unmarried	1.31 (1.10–1.56)	0.002	1.32 (0.93–1.86)	0.120
Differentiation grade	I/II	1		1
	III/IV	1.84 (1.25–2.72)	0.002	1.41 (0.85–2.35)	0.183
Tumour size	<=4	1		1
	> 4	1.37 (1.11–1.69)	0.003	1.02 (0.72–1.45)	0.913
Primary site	Head	1		1
	Body	1.47 (1.10–1.97)	0.009	1.38 (0.78–2.43)	0.272
	Tail	1.29 (1.00–1.66)	0.048	1.45 (0.88–2.38)	0.140
	Other	1.39 (1.01–1.93)	0.045	1.27 (0.72–2.22)	0.412
Regional nodes status	Positive	1		1
	Negative	0.71 (0.48–1.06)	0.097	0.58 (0.35–0.95)	0.031
	No nodes examined	2.53 (1.98–3.24)	< 0.001	0.74 (0.35–1.57)	0.440
Summary stage	Distant	1		1
	Localised/Regional	0.44 (0.36–0.53)	< 0.001	0.66 (0.45–0.97)	0.034
Surgery	No	1		1
	Yes	0.31 (0.24–0.40)	< 0.001	0.30 (0.14–0.65)	0.002
Chemotherapy	No/Unknown	1		1
	Yes	0.41 (0.35–0.49)	< 0.001	0.42 (0.28–0.63)	< 0.001
Radiation	No/Unknown	1		1
	Yes	0.45 (0.35–0.58)	< 0.001	1.07 (0.66–1.74)	0.782

Statistically significant variables are highlighted in bold