Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 16;41:323. doi: 10.1186/s13046-022-02526-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — ARPC1B is significantly associated with the MES phenotype and predicts a poor outcome of GBM. A Kaplan–Meier curves revealing overall survival of TCGA-GBM patients stratified in accordance with ARPs’ expression. B The expression of ARPC1B in normal control and GBM tissues (left panel) and the expression of ARPC1B in mesenchymal (MES), proneural (PN), and classical (CL) phenotypes (right panel) in TCGA GBM. C Western blotting of ARPC1B expression in NPCs, MES-GSCs (GSC 20, GSC 267, and GSC 28) and PN-GSCs (GSC 8-11 and GSC 11). D Single-cell RNA sequencing of GSE138794 visualizing UMAP cell clusters, Verhaak_GBM_MES score and ARPC1B expression. E The correlation of ARPC1B expression with PN-associated (DLL3, OLIG2, ASCL1, NCAM1, and SOX2) and MES-associated genes (CD44, FN1, LYN, CHI3L1, and SERPINE1). F Western blot analysis of ARPC1B, CD44 and YKL-40 protein expression upon ARCP1B knockdown in GSCs. β-Actin served as the control