Table 1.
Ref | Demographics | Clinics | Serum | CSF | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient Number | Age | Sex | Graus criteria fulfilleda | Demyelinating episodes, nb | Follow-up, Moc | Time E – MOG + , Mo | DE symptoms | MOG-IgG status | NMDAR-IgG status | MOG-IgG status | NMDAR-IgG status | OCB status | WBC/µl | |
[3] | 1 | 48 | F | Yes | 2 | 60 | 18 | Yes | positive | positive | positive | positive | positive | 150 |
[3] | 2 | 17 | M | Yes | 2 | 9 | 3 | Yes | n.a | Not applicable | positive | positive | negative | 3 |
[3] | 3 | 27 | F | Yes | 5 | 108 | -48 | Yes | positive | negative | positive | positive | positive | 66 |
[3] | 4 | 34 | M | Yes | 2 | 22 | 3 | Yes | positive | negative | positive | positive | negative | 164 |
[3] | 5 | 10 | M | Yes | 1 | 144 | -96 | Yes | positive | negative | positive | positive | negative | 9 |
[3] | 6 | 29 | M | Yes | 1 | 41 | 36 | Yes | positive | n.a | positive | positive | negative | 0 |
[3] | 7 | 38 | M | Yes | 2 | 60 | -22 | Yes | positive | negative | positive | positive | negative | 2 |
[3] | 8 | 4 | F | Yes | 1 | 7 | 0 | Yes | positive | n.a | positive | positive | positive | n.a |
[3] | 9 | 6 | M | Yes | 1 | 2,5 | 0 | Yes | positive | negative | positive | positive | positive | 43 |
[15] | 10 | 9 | F | Yes | 1 | 18 | 0.5 | Yes | positive | positive | positive | positive | negative | 44 |
[13] | 11 | 31 | M | No | 2 | 15 | 0 | Yes | positive | negative | n.a | positive | negative | 8 |
[12] | 12 | 54 | M | Yes | 0 | 3 | 0 | Yes | positive | n.a | n.a | positive | negative | 28 |
[8] | 13 | 3 | F | Yes | 3 | 252 | -240 | Yes | positive | negative | positive | positive | negative | 0 |
[8] | 14 | 23 | M | Yes | 3 | 44 | -44 | Yes | positive | negative | negative | positive | positive | 0 |
[8] | 15 | 6 | M | Yes | 5 | 54 | 0 | Yes | positive | positive | negative | positive | positive | 8 |
[8] | 16 | 25 | M | Yes | 1 | 0 | 0 | Yes | positive | negative | positive | positive | positive | 96 |
[8] | 17 | 9 | M | Yes | 2 | 18 | 18 | Yes | positive | negative | negative | positive | positive | 2 |
[11] | 18 | 47 | M | n.a | 2 | 60 | 0 | No | positive | positive | positive | positive | negative | 16 |
[4] | 19 | 36 | F | Yes | 1 | 44.5 | 0 | No | positive | n.a | n.a | positive | positive | 116 |
[20] | 20 | 10 | F | Yes | 0 | 36 | 12 | No | positive | n.a | n.a | positive | negative | 576 |
[19] | 21 | 6 | M | Yes | 0 | 3 | 0 | No | positive | n.a | n.a | positive | positive | 0 |
[18] | 22 | 29 | M | Yes | 1 | 4 | 2 | Yes | positive | n.a | n.a | positive | positive | 39 |
[16] | 23 | 12 | M | Yes | 0 | 1.5 | 0 | No | positive | positive | n.a | positive | n.a | 91 |
[21] | 24 | 14 | F | Yes | 3 | 44 | -4 | No | positive | positive | n.a | positive | negative | 256 |
[21] | 25 | 10 | M | Yes | 0 | 6 | 0 | Yes | positive | positive | n.a | positive | n.a | 96 |
[17] | 26 | 19 | M | Yes | 2 | 37 | 18 | Yes | positive | negative | negative | positive | n.a | 292 |
[6] | 27 | 27 | M | Yes | 0 | 4 | 0 | Yes | n.a | n.a | positive | positive | n.a | 5 |
[10] | 28 | 38 | M | Yes | 1 | 6 | 0 | Yes | positive | positive | n.a | n.a | negative | 88 |
[5] | 29 | 37 | M | Yes | 0 | 2 | 0 | No | positive | positive | positive | positive | negative | 50 |
[9] | 30 | 39 | M | Yes | 2 | 60 | 0 | No | positive | n.a | positive | positive | n.a | 112 |
[7] | 31 | 30 | M | Yes | 0 | 12 | 0 | Yes | positive | positive | n.a | positive | n.a | n.a |
Total | 31 | 25 (3–54) | Female: 8 (25.8%) | 29 (94%) | 1 (0–5) | 18 (0–252) | 0 (-240–36) | 23 (74%) | Positive: 29 | Positive: 10 | Positive: 16 | Positive: 30 | Positive: 11 | 43 (0–576) |
Legend: CSF Cerebrospinal fluid, DE Demyelination, E NMDAR-encephalitis, F Female, IgG Immunoglobulin G, MO Months, M Male, MOG Myelin oligodendrocyte glycoprotein, MOG + MOG IgG positivity, N Number, NMDAR N-methyl-D-aspartate receptor, OCB Oligoclonal bands, Ref Reference, WBC White blood cell count
a Diagnostic criteria for definite NMDAR encephalitis according to Graus et al. [26]
b Demyelinating episodes during or after NMDAR-encephalitis were considered
c Follow-Up after NMDAR-encephalitis