Table 1.
Baseline characteristics of group 1, the most rapidly cooled patients, with an average temperature of < 34 °C at 4 h (240 min) post ROSC
| Normothermia | Hypothermia | |
|---|---|---|
| Total number | 150 | 146 |
| Age (mean (SD)) | 63.77 (12.80) | 65.08 (12.74) |
| Sex = male (%) | 120 (80.0) | 113 (77.4) |
| Body weight (mean (SD)) | 83.11 (14.96) | 83.82 (17.16) |
| BMI (mean (SD)) | 27.07 (5.12) | 27.40 (5.38) |
| Hypertension—no. (%) | 52 (47.3) | 55 (49.5) |
| Myocardial infarction—no. (%) | 27 (31.8) | 30 (35.3) |
| PCI—no. (%) | 30 (34.1) | 24 (30.0) |
| Coronary artery bypass grafting—no. (%) | 17 (22.7) | 12 (17.6) |
| Heart failure—no. (%) | 22 (27.8) | 13 (18.8) |
| NYHA III or IV heart failure—no. (%) | 1 (10.0) | 3 (37.5) |
| Median Charlson comorbidity index (median [IQR]) | 3.00 [1.00, 4.00] | 3.00 [2.00, 4.00] |
| Location at cardiac arrest (%) | ||
| Home | 71 (47.3) | 88 (60.3) |
| Other | 23 (15.3) | 13 ( 8.9) |
| Public place | 56 (37.3) | 45 (30.8) |
| Bystander performed CPR (%) | 122 (81.3) | 116 (79.5) |
| Bystander witnessed cardiac arrest | 137 (91.3) | 131 (89.7) |
| Initial rhythm (%) | ||
| Asystole | 15 (10.0) | 26 (17.8) |
| Non-perfusing VT | 2 (1.3) | 3 ( 2.1) |
| PEA | 17 (11.3) | 24 (16.4) |
| ROSC after bystander defibrillation | 5 (3.3) | 0 ( 0.0) |
| Unknown—No shock administered | 1 (0.7) | 2 ( 1.4) |
| Unknown—Shock administered | 3 (2.0) | 5 ( 3.4) |
| VF | 107 (71.3) | 86 (58.9) |
| Median time from cardiac arrest to ROSC (min, median [IQR]) | 27.50 [15.25, 38.75] | 27.00 [18.00, 40.75] |
| Median time from cardiac arrest to randomization (min, mean (SD)) | 124.13 (47.51) | 127.68 (43.75) |
| Admission tympanic temperature (mean (SD)) | 35.26 (1.24) | 34.70 (1.32) |
| Admission FOUR motor score (median [IQR]) | 0.00 [0.00, 0.00] | 0.00 [0.00, 0.00] |
| Bilateral corneal reflexes present (no. %) | 17 (23.0) | 15 (21.7) |
| Bilateral pupillary reflexes present (no. %) | 65 (59.6) | 71 (67.0) |
| Admission arterial pH (mean (SD)) | 7.17 (0.16) | 7.16 (0.18) |
| Admission arterial lactate mmol/l (median [IQR]) | 5.70 [2.80, 8.55] | 5.60 [2.80, 8.20] |
| Shock on admission = (no. (%) | 44 (29.3) | 44 (30.1) |
| ST segment elevation myocardial infarction (no. (%) | 68 (45.9) | 59 (40.7) |
SD, standard deviation; BMI, body mass index; PCI, percutaneous coronary intervention; CPR, cardio-pulmonary resuscitation; VT, ventricular tachycardia; VF, ventricular fibrillation; PEA, pulseless electrical activity; ROSC, return of spontaneous circulation