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(A) Regions of interest (ROI) used in the investigation of R2 differences in LATE-NC stages 1, 2, 3 compared to stage 0. WM stands for white matter. (B) Mean adjusted R2 value and 95% confidence interval for each LATE-NC stage and each ROI. R2 values have been adjusted for neuropathologies (other than LATE-NC), demographics, scanners, and postmortem intervals.
