Table 2.
Neuropathologic characteristics of the participants.
| Characteristics | |
|---|---|
| N | 738 |
| LATE-NC, n (%) | |
| (stage 0) no TDP-43 inclusions | 319 (43.2) |
| (stage 1) TDP-43 inclusions in amygdala only | 130 (17.6) |
| (stage 2) TDP-43 inclusions in amygdala and entorhinal cortex or hippocampus | 81 (11) |
| (stage 3) TDP-43 inclusions in amygdala, entorhinal cortex or hippocampus, and neocortex | 208 (28.2) |
| AD-NC (NIA-AA criteria), n (%) | |
| None | 61 (8.2) |
| Low | 132 (17.9) |
| Intermediate | 346 (46.9) |
| High | 199 (27) |
| Lewy bodies, n (%) | 217 (29.4) |
| Gross infarcts, n (%) | 298 (40.4) |
| Microscopic infarcts, n (%) | 291 (39.4) |
| Cerebral amyloid angiopathy, n (%) | |
| None | 145 (19.7) |
| Mild | 324 (43.9) |
| Moderate | 181 (24.5) |
| Severe | 88 (11.9) |
| Atherosclerosis, n (%) | |
| None | 174 (23.6) |
| Mild | 394 (53.4) |
| Moderate | 139 (18.8) |
| Severe | 31 (4.2) |
| Arteriolosclerosis, n (%) | |
| None | 273 (37) |
| Mild | 277 (37.5) |
| Moderate | 149 (20.2) |
| Severe | 39 (5.3) |
AD-NC, Alzheimer’s Disease neuropathological change; LATE-NC, Limbic predominant age-related transactive response DNA binding protein 43 (TDP-43) encephalopathy neuropathological change; NIA-AA, National Institute on Aging-Alzheimer’s Association.