Table 3.
Results of linear regression testing the hypothesis that regional R2 values in LATE-NC stages 1, 2, 3 are lower than those in stage 0, controlling for other pathologies, demographics, scanners, and postmortem intervals.
| LATE-NC Stage 1 vs. 0 βa (p-value) |
LATE-NC Stage 2 vs. 0 βa (p-value) |
LATE-NC Stage 3 vs. 0 βa (p-value) |
Arteriolosclerosis βb (p-value) |
Atherosclerosis βb (p-value) |
CAA βb (p-value) |
Gross infarcts βb (p-value) |
Lewy Bodies βb (p-value) |
A score βb (p-value) |
B score βb (p-value) |
C score βb (p-value) |
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| Amygdala | − 0.2 (0.46) | − 0.8 (3×10−4) | − 0.9 (1×10−4) | − 0.1 (0.15) | 0 (0.86) | 0.1 (0.06) | − 0.1 (0.46) | − 0.4 (5×10 −3 ) | − 0.1 (0.54) | − 0.4 (1×10 −4 ) | 0 (0.84) |
| Hippocampus | − 0.1 (0.62) | − 0.6 (3×10−3) | − 0.7 (1×10−4) | − 0.1 (0.52) | 0 (0.84) | 0.2 (0.03) | − 0.1 (0.54) | − 0.2 (0.18) | − 0.2 (0.19) | − 0.4 (1×10 −4 ) | 0.1 (0.54) |
| Parahippocampal WM | − 0.1 (0.77) | − 0.7 (1×10−3) | − 1.2 (1×10−4) | 0 (0.86) | 0 (0.88) | 0.2 (0.04) | − 0.1 (0.58) | − 0.4 (0.02) | 0 (0.89) | − 0.6 (1×10 −4 ) | − 0.1 (0.61) |
| Temporal Pole WM | − 0.3 (0.23) | − 0.5 (0.03) | − 0.8 (1×10−4) | 0 (0.84) | 0 (0.85) | 0.1 (0.37) | − 0.1 (0.62) | − 0.1 (0.66) | 0 (0.87) | − 0.3 (0.04) | − 0.2 (0.2) |
| Temporal Lobe WM | − 0.3 (0.47) | − 0.4 (0.39) | − 1.3 (1×10−4) | 0 (0.83) | 0 (0.81) | 0 (0.85) | − 0.2 (0.2) | − 0.3 (0.37) | 0.1 (0.8) | − 0.8 (1×10 −4 ) | − 0.1 (0.62) |
| Insular WM | − 0.4 (0.22) | − 0.5 (0.17) | − 1.2 (1×10−4) | − 0.1 (0.69) | 0 (0.83) | 0.1 (0.33) | − 0.4 (3×10 −3 ) | − 0.3 (0.23) | − 0.1 (0.57) | − 0.5 (1×10 −3 ) | 0 (0.88) |
| Medial Orbitofrontal WM | − 0.2 (0.6) | − 0.3 (0.53) | − 0.6 (6×10−3) | − 0.2 (0.14) | − 0.1 (0.49) | 0.3 (0.02) | − 0.4 (9×10 −4 ) | − 0.1 (0.6) | 0.1 (0.76) | − 0.5 (4×10 −3 ) | − 0.2 (0.15) |
| Occipitotemporal cortex | − 0.3 (0.4) | − 0.6 (0.11) | − 0.7 (3×10−3) | 0 (0.84) | 0.1 (0.72) | 0 (0.87) | − 0.3 (0.07) | − 0.3 (0.36) | − 0.2 (0.33) | − 0.8 (1×10 −4 ) | 0.1 (0.72) |
| Parietal WM | − 0.1 (0.84) | − 0.1 (0.79) | 0 (0.88) | − 0.2 (0.29) | 0.2 (0.39) | − 0.3 (0.04) | − 0.6 (1×10 −4 ) | − 0.2 (0.57) | 0.1 (0.71) | − 0.5 (3×10 −3 ) | 0 (0.82) |
CAA, cerebral amyloid angiopathy; WM, white matter
Statistically significant findings are shown in bold (p<0.05). FWER (family-wise error rate) corrected p-values are shown in parentheses.
a
Coefficient denoting the difference in R2 between two LATE-NC stages (units: sec−1)
b
Coefficient denoting the difference in R2 between consecutive levels of the pathology variable (units: sec−1)