Table 2-. Comparison of genotype frequencies of TLR4, CARD14 and PSORS1C3 variants between psoriatic patients and controls.
| SNP | Gene | Test model | Controls (n=46) | Patients (n=71) | OR | 95% CI | p-Value |
|---|---|---|---|---|---|---|---|
| rs887464 | PSORS1C3 | GG | 20 (43.48%) | 32 (45.07%) | |||
| GA | 24 (52.17%) | 21 (29.58%) | 0.5469 | 0.2434 - 1.2286 | 0.065(2) | ||
| AA | 2 (4.35%) | 18 (25.35%) | 5.625 | 1.1772 - 26.8779 | 0.001(1) | ||
| rs3868542 | PSORS1C3 | AA | 18 (39.13%) | 30 (42.25%) | |||
| AG | 22 (47.83%) | 28 (39.44%) | 0.7636 | 0.3403 - 1.7136 | 0.44(2) | ||
| GG | 6 (13.04%) | 13 (18.31%) | 1.3 | 0.4199 - 4.0250 | 0.673(1) | ||
| rs11507945 | PSORS1C3 | CC | 23 (50%) | 33 (46.48%) | |||
| CT | 23 (50%) | 30 (42.25%) | 0.9091 | 0.4249 - 1.9451 | 0.772(2) | ||
| TT | 0 (0%) | 8 (11.27%) | 11.9254 | 0.6558 - 216.8568 | 0.001(1) | ||
| rs3871247 | PSORS1C3 | CC | 18 (39.13%) | 29 (40.85%) | |||
| CT | 25 (54.35 %) | 29 (40.85%) | 0.72 | 0.3251 - 1.5944 | 0.292(2) | ||
| TT | 3 (6.52%) | 13 (18.3%) | 2.6897 | 0.6724 - 10.7591 | 0.673(1) | ||
| rs369029873 | PSORS1C3 | GG | 27 (58.7%) | 47 (66.2%) | |||
| GA | 19 (41.3%) | 24 (33.8%) | 0.7256 | 0.3374 - 1.5605 | 0.381(2) | ||
| rs3130506 | PSORS1C3 | CC | 2 (4.35%) | 7 (9.86%) | |||
| CT | 23 (50%) | 32 (45.07%) | 0.3975 | 0.0756 - 2.0913 | 0.151(2) | ||
| TT | 21 (45.65%) | 32 (45.07%) | 0.4354 | 0.0824 - 2.3015 | 0.157(2) | ||
| rs3871246 | PSORS1C3 | AA | 18 (39.13%) | 32 (45.07%) | |||
| AG | 25 (54.35%) | 27 (38.03%) | 0.6075 | 0.2748 - 1.3431 | 0.131(2) | ||
| GG | 3 (6.52%) | 12 (16.9%) | 2.25 | 0.5600 - 9.0400 | 0.163(1) | ||
| rs11967629 | PSORS1C3 | GG | 23 (50%) | 35 (49.3%) | |||
| GA | 23 (50%) | 28 (39.44%) | 0.8 | 0.3733 - 1.7145 | 0.467(2) | ||
| AA | 0 (0%) | 8 (11.27%) | 11.2535 | 0.6195 - 204.4117 | 0.002(1) | ||
| +280 | PSORS1C3 | AA | 40 (86.96%) | 48 (67.61%) | |||
| AG | 6 (13.04%) | 23 (32.39%) | 3.1944 | 1.1850 - 8.6112 | 0.002(2) | ||
| rs11653893 | CARD14 | AA | 14 (30.43%) | 14 (19.72%) | |||
| AG | 18 (39.13%) | 43 (60.56%) | 2.3889 | 0.9494 - 6.0112 | 0.023(2) | ||
| GG | 14 (30.43%) | 14 (19.72%) | 1 | 0.3508 - 2.8510 | 1(1) | ||
| rs189286068 | CARD14 | CC | 43 (93.48%) | 67 (93.37%) | |||
| CT | 3 (6.52%) | 4 (6.63%) | 0.8557 | 0.1825 - 4.0124 | 1(1) | ||
| c.3150 p.T812A/S | CARD14 | AA | 45 (97.83%) | 68(95.77%) | |||
| AG | 1 (2.17%) | 2 (2.82%) | 1.3235 | 0.1165 - 15.0318 | 0.683(1) | ||
| AT | 0 | 1 (1.41%) | 0.6618 | 0.0403 - 10.8535 | 0.497(1) | ||
| rs11652075 | CARD14 | CC | 14 (30.43%) | 17 (23.94%) | |||
| CT | 18 (39.13%) | 40 (56.33%) | 1.8301 | 0.7441 - 4.5008 | 0.124(2) | ||
| TT | 14 (30.43%) | 14 (19.72%) | 0.8235 | 0.2957 - 2.2936 | 0.694(1) | ||
| rs61757652 | CARD14 | CC | 30 (65.22%) | 54 (76.06%) | |||
| CT | 16 (34.78%) | 17 (23.94%) | 0.5903 | 0.2611 - 1.3344 | 0.121(1) | ||
| rs1486223942 | CARD14 | CC | 46 (100%) | 69 (97.18%) | |||
| CT | 0 | 2 (2.82%) | 3.3453 | 0.1570 - 71.2792 | 0.246(1) | ||
| c.3285+54 | CARD14 | CC | 46 (100%) | 68 (95.77%) | |||
| CG | 0 | 3 (4.23%) | 4.7518 | 0.2398 - 94.1681 | 0.121(1) | ||
| rs376428578 | CARD14 | CC | 12 (26.09%) | 44 (61.97%) | |||
| CA | 34 (73.91%) | 27 (38.03%) | 0.2166 | 0.0960 - 0.4888 | <0.001(2) | ||
| rs2149356 | TLR4 | TT | 3 (6.52%) | 6 (8.45%) | |||
| TG | 23 (50%) | 30 (42.25%) | 0.6522 | 0.1472 - 2.8897 | 0.781(2) | ||
| GG | 20 (43.48%) | 35 (49.3%) | 0.875 | 0.1970 - 3.8858 | 1(2) | ||
| c.331-428 | TLR4 | TT | 32 (69.57%) | 51 (71.83%) | |||
| TG | 14 (30.43%) | 20 (28.17%) | 0.8964 | 0.3973 - 2.0221 | 0.876(1) | ||
| c.331-200 | TLR4 | GG | 45 (97.83%) | 68 (95.77%) | |||
| GA | 1 (2.17%) | 3 (4.23%) | 1.9853 | 0.2002 - 19.6899 | 0.683(1) | ||
| c.331-102 | TLR4 | TT | 45 (97.83%) | 66 (92.96%) | |||
| TA | 1 (2.17%) | 5 (7.04%) | 3.4091 | 0.3853 - 30.1654 | 0.088(1) | ||
| c.331-1 | TLR4 | GG | 45 (97.83%) | 68 (95.77%) | |||
| GC | 1 (2.17%) | 3 (4.23%) | 1.9853 | 0.2002 - 19.6899 | 0.683(1) | ||
| rs770576183 | TLR4 | GG | 46 (100%) | 69 (97.18%) | |||
| GC | 0 (0%) | 1 (1.41%) | 2.0072 | 0.0800 - 50.3437 | 0.495(1) | ||
| GA | 0 (0%) | 1(1.41%) | 2.0072 | 0.0800 - 50.3437 | 0.495(1) | ||
| rs1018673641 | TLR4 | AA | 44 (95.65%) | 60 (84.5%) | |||
| AT | 2 (4.35%) | 11 (15.5%) | 4.0333 | 0.8509 - 19.1187 | 0.008(1) | ||
| c.371 p.L101 L | TLR4 | CC | 27 (58.7%) | 41 (57.75%) | |||
| CT | 19 (41.3%) | 30 (42.25%) | 1.0398 | 0.4899 - 2.2067 | 1(2) | ||
| c.376 p.S102S | TLR4 | CC | 20 (43.48%) | 40 (56.34%) | |||
| CT | 26 (56.52%) | 31 (43.66%) | 0.5962 | 0.2821 - 1.2598 | 0.089(2) |
P-values were calculated by either Fisher’s exact test (1) or Chi-squared test (2); p < 0.05 (in bold) indicates statistical significance from healthy donors; OR: Odds ratio; 95% CI: 95% confidence interval of odds ratio.