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. Author manuscript; available in PMC: 2022 Nov 16.
Published in final edited form as: Nat Aging. 2022 Oct 12;2(10):941–955. doi: 10.1038/s43587-022-00287-9

Fig. 6. The Skin is a Major Reservoir of Pathobionts and Plasmid-borne Antimicrobial Resistance in Older Adults.

Fig. 6.

Only the in-house YA cohort was used. (A) Presence (red) or absence (black) of pathobiont. None of these organisms were detected at any level in our environmental or reagent negative controls. (B) Abundance heatmap of plasmid antimicrobial resistance gene (ARG) class. Each column represents one individual, with one timepoint plotted per volunteer. For (A) and (B), blue and gray patterned tiles, respectively, are samples not represented because they were not collected as part of this study or had insufficient sequencing depth to be included in the analysis. Actual relative abundances are shown in table S4. (C) Differential abundance of plasmid ARG classes between CD and SNFD cohorts. Log2fold change in relative abundance is shown, with positive values representing enrichment in SNFD. Only significant differences (fdr adjusted p < 0.05) were plotted. RPM = reads mapped per million. Analogous analyses using the expanded YA cohort are reported in fig. S18.