Table 2.

IKZF1, ERG, and TP53 Alterations in DUX4-r ALL

Alteration	TPOG, no. (%) (n = 252)	Zhang et al16 (n = 1743)		Lilljebjörn et al22 (n = 195)		Liu et al18 (n = 94)
		No. (%)	P∗	No. (%)	P∗	No. (%)	P∗
DUX4-r ALL	15† (6.0)	134 (7.7)	0.37	8 (4.1)	0.52	6 (6.4)	>0.99
IKZF1
Deletion	7 (50)	27 (23.3)	0.02	1 (12.5)	0.07	3 (50.0)	>0.99
Wild type	7 (50)	89 (76.7)		7 (87.5)		3 (50.0)
ERG
Deletion	3 (21.4)	68 (59.1)	0.002	6 (75.0)	0.008	4 (66.7)	>0.99
Wild type	11 (88.6)	47 (40.9)		2 (25.0)		2 (33.3)
TP53
Mutation	2 (14.3)	2 (3.3)	0.04	0 (0.0)	0.27	0 (0.0)	0.52
Wild type	12 (85.7)	59 (96.7)		8 (100.0)		6 (100.0)

ALL, acute lymphoblastic leukemia; TPOG, Taiwan Pediatric Oncology Group.

^∗P values were calculated using the Fisher exact test between this study and previous studies.^16,18

^†Material was not available for one case for genetic alteration analysis.