Table 2.
Echocardiographic parameters in patients with and without ATTR-CM.
| Characteristic | No ATTR-CM (n=274) | ATTR-CM (n=324) | p-value |
|---|---|---|---|
| IVS d (mm) | 13.8 ± 3.6 | 17.1± 3.2 | <0.001 |
| PW d (mm) | 12.6 ± 3.1 | 16.5 ± 3.4 | <0.001 |
| LV ED d (mm) | 45.5 ± 8.1 | 42.0 ± 6.5 | <0.001 |
| LV ES d (mm) | 32.9 ± 9.1 | 33.2 ± 7.1 | 0.64 |
| LA d (mm) | 46.0 ± 9.6 | 45.7 ± 6.5 | 0.61 |
| LAVI (ml/m2) | 47.0 21.1 | 46.4 13.6 | 0.76 |
| LV EF (%) | 51.5 ± 12.5 | 48.2 ± 11.7 | 0.001 |
| LV mass (g) | 235.8 ± 80.5 | 300.0 ± 81.2 | <0.001 |
| LV mass index (g/m 2 ) | 119.9 ± 37.9 | 153.1 ± 37.9 | <0.001 |
| E wave (m/s) | 0.93 ± 0.32 | 0.86 ± 0.22 | 0.003 |
| A wave (m/s) * | 0.78 [0.53, 1.0] | 0.34 [0.23, 0.56] | <0.001 |
| e’ septal (cm/s) | 5 [4, 6] | 4 [3, 5] | <0.001 |
| e’ lateral (cm/s) | 7 [5, 9] | 5 [4, 7] | <0.001 |
| E/A * | 0.96 [0.72, 1.75] | 2.1 [1.3, 3.12] | <0.001 |
| E/e’ | 14.7 [10.6, 20.3] | 17.4 [13.9, 22.8] | <0.001 |
| DT (msec) | 192 ± 61 | 183 ± 53 | 0.03 |
| TAPSE (mm) * | 16.0 ± 5.3 | 13.6 ± 5.0 | <0.001 |
| RV s’ (cm/s) | 10.6 ± 3.4 | 8.8 ± 2.8 | <0.001 |
| TR Vmax (m/s) | 2.7 ± 0.6 | 2.5 ± 0.5 | 0.01 |
| MCF * | 0.32 ± 0.16 | 0.18 ± 0.09 | <0.001 |
| Relative Wall Thickness | 0.58 ± 0.20 | 0.81 ± 0.24 | <0.001 |
| Eccent. Ratio | 1.06 [0.92, 1.27] | 1.02 [0.92, 1.16] | 0.01 |
d, diameter; DT, deceleration time; Eccent., eccentricity; ED, end diastolic; EF, ejection fraction; ES, end systolic; IVS, interventricular septum; LA, left atrial; LV, left ventricular; MCF, myocardial contraction fraction; PW, posterior wall; RV, right ventricular; TR, tricuspid regurgitation; Vmax, maximum velocity.
Data is displayed as mean ± standard deviation for normally distributed data, median [interquartile range] otherwise.
*
parameter not measured in entire cohort as detailed in text