Table 5:
Diagnostic performance of IWT & TCAS scores for ATTR-CM
| IWT Score | TCAS score | Inferolateral Wall Thickness | Basal Longitudinal Strain | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cut point | Sensitivity | Specificity | Correctly Classified | Cut point | Sensitivity | Specificity | Correctly Classified | Cut-point (mm) | Sensitivity | Specificity | Correctly Classified | Cut-point (%) | Sensitivity | Specificity | Correctly Classified |
| ≥ 0 | 100.00% | 0.00% | 66.99% | ≥ 0 | 100.00% | 0.00% | 51.73% | (≥ 7) | 99.69% | 0.00% | 54.01% | (≥ −20) | 100.00% | 4.19% | 60.31% |
| ≥ 1 | 98.55% | 6.86% | 68.28% | ≥ 1 | 100.00% | 0.45% | 51.95% | (≥ 8) | 99.69% | 2.55% | 55.18% | (≥ −19) | 100.00% | 5.12% | 60.69% |
| ≥ 2 | 98.07% | 8.82% | 68.61% | ≥ 2 | 99.58% | 3.14% | 53.03% | (≥ 9) | 99.07% | 9.49% | 58.03% | (≥ −18) | 99.67% | 6.51% | 61.08% |
| ≥ 3 | 96.62% | 17.65% | 70.55% | ≥ 3 | 99.58% | 8.97% | 55.84% | (≥ 10) | 98.15% | 17.15% | 61.04% | (≥ −17) | 99.67% | 8.37% | 61.85% |
| ≥ 4 | 95.17% | 32.35% | 74.43% | ≥ 4 | 98.33% | 17.04% | 59.09% | (≥ 11) | 95.99% | 25.91% | 63.88% | (≥ −16) | 99.34% | 12.09% | 63.20% |
| ≥ 5 | 86.96% | 54.90% | 76.38% | ≥ 5 | 97.49% | 28.70% | 64.29% | (≥ 12) | 92.90% | 38.32% | 67.89% | (≥ −15) | 99.34% | 15.35% | 64.55% |
| ≥ 6 | 85.02% | 59.80% | 76.70% | ≥ 6 | 93.72% | 50.22% | 72.73% | (≥ 13) | 87.35% | 50.73% | 70.57% | (≥ −14) | 99.01% | 20.47% | 66.47% |
| ≥ 7 | 80.19% | 67.65% | 76.05% | ≥ 7 | 83.68% | 70.85% | 77.49% | (≥ 14)* | 81.48% | 62.41% | 72.74% | (≥ −13 | 98.36% | 25.58% | 68.21% |
| ≥ 8 | 48.31% | 84.31% | 60.19% | ≥ 8 | 64.85% | 85.65% | 74.89% | (≥ 15) | 73.46% | 71.90% | 72.74% | (≥ −12) | 97.37% | 32.56% | 70.52% |
| ≥ 9 | 42.03% | 87.25% | 56.96% | ≥ 9 | 30.13% | 93.27% | 60.61% | (≥ 16) | 61.42% | 83.94% | 71.74% | (≥ −11) | 95.72% | 40.47% | 72.83% |
| ≥ 10 | 37.20% | 88.24% | 54.05% | ≥ 10 | 5.02% | 99.55% | 50.65% | (≥ 17) | 51.23% | 90.88% | 69.40% | (≥ −10) | 92.76% | 49.30% | 74.76% |
| > 10 | 0.00% | 100.00% | 48.27% | (≥ 18) | 41.67% | 94.16% | 65.72% | (≥ −9) | 87.50% | 58.14% | 75.34% | ||||
| (≥ 19) | 29.94% | 95.99% | 60.20% | (≥ −8)* | 81.91% | 68.37% | 76.30% | ||||||||
| (≥ 20) | 18.83% | 97.81% | 55.02% | (≥ −7) | 73.36% | 78.14% | 75.34% | ||||||||
| (≥ 21) | 11.42% | 98.91% | 51.51% | (≥ −6) | 60.20% | 85.12% | 70.52% | ||||||||
| (≥ 22) | 5.86% | 98.91% | 48.49% | (≥ −5) | 47.04% | 92.09% | 65.70% | ||||||||
| (≥ 23) | 3.40% | 99.64% | 47.49% | (≥ −4) | 27.63% | 97.21% | 56.45% | ||||||||
| (≥ 24) | 2.47% | 100.00% | 47.16% | (≥ −3) | 12.83% | 100.00% | 48.94% | ||||||||
IWT, Increased Wall Thickness; TCAS, Mayo clinic derived Transthyretin Cardiac Amyloidosis score.
*
Chosen cut-off