Figure 5:
Induction of drug-metabolizing enzymes in Caco2-AhRKO cells. Caco2-AhRKO cells were treated 24 hours with 6-,4′- and 3′- hydroxyflavone and 6,3′- and 5,6-dihydroxyflavone. Induction of (A) CYP1A1, (B) CYP1B1 and (C) UGT1A1 were determined by real-time PCR. Results are expressed as means ± SE for at least 3 replicate determinations and significant (p<0.01) induction is indicated (*).