TABLE 3.
Performance of WGS-AST for Gram-negative-active antibiotics across the species testeda
| Compound | Categorical agreement (%) | VME (%) | ME (%) | No. of samples |
|||
|---|---|---|---|---|---|---|---|
| TN | FP | FN | TP | ||||
| All | 95 | 11 | 4 | 269 | 11 | 4 | 31 |
| Amikacin | 100 | 0 | 22 | 0 | 0 | 0 | |
| Amoxicillin-clavulanic acid | 82 | 20 | 17 | 10 | 2 | 1 | 4 |
| Ampicillin | 100 | 0 | 0 | 6 | 0 | 0 | 10 |
| Cefazolin | 71 | 0 | 33 | 10 | 5 | 0 | 2 |
| Cefepime | 100 | 0 | 0 | 18 | 0 | 0 | 1 |
| Cefoxitin | 93 | 7 | 13 | 1 | 0 | 0 | |
| Ceftazidime | 96 | 0 | 5 | 19 | 1 | 0 | 2 |
| Ceftriaxone | 95 | 50 | 0 | 18 | 0 | 1 | 1 |
| Ciprofloxacin | 96 | 0 | 4 | 25 | 1 | 0 | 1 |
| Gentamicin | 100 | 0 | 0 | 24 | 0 | 0 | 1 |
| Meropenem | 100 | 0 | 22 | 0 | 0 | 0 | |
| Norfloxacin | 100 | 0 | 0 | 13 | 0 | 0 | 1 |
| Piperacillin-tazobactam | 100 | 0 | 0 | 15 | 0 | 0 | 1 |
| Sulfamethoxazole-trimethoprim | 90 | 25 | 6 | 15 | 1 | 1 | 3 |
| Ticarcillin-clavulanic acid | 67 | 100 | 0 | 2 | 0 | 1 | 0 |
| Tobramycin | 100 | 0 | 0 | 24 | 0 | 0 | 1 |
| Trimethoprim | 100 | 0 | 0 | 13 | 0 | 0 | 3 |
a
VME, very major errors; ME, major errors; TN, true negative; FP, false positive; FN, false negative; TP, true positive. Blank cells indicate insufficient data.