Examples of β-lactamase inhibitors, their β-lactam adjuvant and the β-lactamase class inhibited^59,60 (compiled with the aid of the Comprehensive Antibiotic Resistance Database; CARD; https://card.mcmaster.ca)⁴⁰.

Name of inhibitor	β-Lactam	β-Lactamase class inhibited	Ref.
Approved inhibitors
Clavulanic acid	Amoxicillin or ticarcillin	Class A, some class D	61, 62
Tazobactam	Piperacillin	Class A, some class D	63
Sulbactam	Ampicillin or cefoperazone	Class A	64, 65
Avibactam	Ceftazidime	Class A, C, D	66
Relebactam	Imipenem/cilastatin	Class A, C	67, 68
Vaborbactam	Meropenem	Class A, C	67
Developmental inhibitors in clinical trials
Nacubactam	Meropenem – phase I trial	Class A, C	69, 70
Zidebactam	Cefepime – phase III trial	Class A, C	71
ETX2514	Sulbactam – phase II trial	Class A, C and some D	72
ETX0282	Cefpodoxime – phase I trial	Class A, C	73
LN-1-255	Ceftazidime – phase II trial	Class A, D (non-carbapenemases)	74
Enmetazobactam	Cefepime – phase III trial	Class A	75, 76
Taniborbactam	Cefepime – phase II trial	Class A, B, C, D	77
VNRX-7145	Cefibutin – phase I trial	Class A, C, D	78
LK-157	Cefuroxime – phase I trial	Class A, C	78
BLI-489	Piperacillin – phase II trial	Class A, C, D	79
d-Captopril	Meropenem – phase I trial	Class B	80