Examples of aminoglycoside N-acetyltransferases (AACs) and their substrates (compiled with the aid of the Comprehensive Antibiotic Resistance Database; CARD; https://card.mcmaster.ca)40.
| Enzyme | Gene coding enzyme | Pathogenic bacterial expression | Aminoglycoside substrate | Ref. |
|---|---|---|---|---|
| AAC(1)-I | aac(1) | Campylobacter fetus, E. coli | Paromomycin | 97 |
| Neomycin | ||||
| AAC(3)-I | aac(3)-Ib | E. coli, Enterobacter cloacae, K. pneumoniae, P. aeruginosa | Gentamicin | 98 |
| AAC(3)-II | aac(3)-II | A. baumannii, E. coli | Gentamicin | 99 |
| Tobramycin | ||||
| Kanamycin | ||||
| AAC(3)-III | aac(3)-III | P. aeruginosa | Tobramycin | 100 |
| Gentamicin | ||||
| Kanamycin | ||||
| Neomycin | ||||
| AAC(3)-IV | aac(3)-IV | E. coli, Campylobacter jejuni | Netilmicin | 101 |
| Dibekacin | ||||
| Apramycin | ||||
| AAC(3)-VI | aac(3)-VI | E. cloacae, Salmonella enterica | Apramycin | 102 |
| AAC(2′)-I | aac(2′)-I | A. baumannii | Tobramycin | 103 |
| Gentamicin | ||||
| Neomycin | ||||
| AAC(2′)-II | aac(2′)-II | Providencia stuartii | Gentamicin | 104 |
| Tobramycin | ||||
| Netilmicin | ||||
| AAC(6′)-I | aac(6′)-I | P. aeruginosa | Tobramycin | 105 |
| Amikacin | ||||
| Kanamycin | ||||
| AAC(6′)-II | aac(6′)-II | K. pneumoniae | Tobramycin | 106 |
| Gentamicin | ||||
| Kanamycin |