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. 2022 Sep 22;13(11):1276–1299. doi: 10.1039/d2md00263a

Substrates of the aminoglycoside nucleotidyltransferases (ANTs)12,110.

Enzyme Bacterial expression Aminoglycoside substrates
ANT(2′′) P. aeruginosa, E. coli, most ESCAPPM Tobramycin, gentamicin, kanamycin
ANT(3′′)-I A. baumannii, Pseudomonas spp., Vibrio spp., E. coli, Yersinia enterocolitica Streptomycin, spectinomycin
ANT(4′)-Ia S. epidermidis, S. aureus, Enterococcus spp., Bacillus spp. Tobramycin, amikacin, kanamycin
ANT(4′)-IIa P. aeruginosa, Enterobacteriaceae Tobramycin, amikacin, kanamycin
ANT(6′)-I C. fetus, E. faecium, S. aureus, E. faecalis, Streptococcus spp., Bacillus spp., C. jejuni Streptomycin
ANT(9)-I S. aureus, Enterococcus spp., Staphylococcus sciuri, E. faecalis Spectinomycin