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. 2022 Sep 22;13(11):1276–1299. doi: 10.1039/d2md00263a

Substrates of aminoglycoside O-phosphotransferases (APHs) and their pathogenic hosts12,110.

Enzyme Subtype Pathogenic host Aminoglycoside substrates
APH(3′) I E. coli, S. enterica, K. pneumoniae, A. baumannii, Citrobacter spp. Kanamycin, neomycin, paromomycin
II E. coli, P. aeruginosa, S. maltophilia Kanamycin, neomycin, paromomycin
III S. aureus, Enterococcus spp. Kanamycin, neomycin, paromomycin, amikacin
IV B. circulans Kanamycin, neomycin, paromomycin
V Streptomyces fradiae, Streptomyces ribosidificus Neomycin, paromomycin
VI A. baumannii, K. pneumoniae, S. marcescens Kanamycin, neomycin, paromomycin, amikacin
VII C. jejuni Kanamycin, neomycin
APH(2′′) I–IV S. aureus, C. difficile, E. faecium, E. coli, Enterococcus gallinarum Kanamycin, gentamicin, tobramycin
APH(3′′) Ia, Ib S. griseus, Enterobacteriaceae, Pseudomonas spp., M. fortuitum Streptomycin
APH(6) Ia, Ib, Ic, Id P. aeruginosa, E. coli, Salmonella spp., V. cholerae Streptomycin
APH(9) Ia, Ib L. pneumophila Spectinomycin