Macrolide deactivating enzymes, their hosts and the antibiotics that they modify (compiled with the aid of the Comprehensive Antibiotic Resistance Database; CARD; https://card.mcmaster.ca)⁴⁰.

Enzyme	Gene	Host	Substrate	Ref.
Esterase (Ere)	ereA	E. coli, K. pneumonia, P. aeruginosa, V. cholera	Erythromycin, roxithromycin, clarithromycin	155
	ereB	E. coli, Salmonella spp.	Erythromycin, roxithromycin, clarithromycin, azithromycin	148
	ereC	K. pneumoniae	14-Membered macrolactones (e.g. clarithromycin, erythromycin, oleandomycin, roxithromycin, solithromycin) except telithromycin	156
	ereD	Riemerella anatipestifer	Erythromycin	157
Glycosyltransferase	gimA	Streptomyces ambofaciens	Oleandomycin	158
	ole	Streptomyces antibioticus	Oleandomycin, tylosin	159
	mgt	S. lividans	Erythromycin, azithromycin	150, 160
Phosphotransferase	mphA	E. coli, A. baumannii, ESCAPPM	14- and 15-membered macrolactones (e.g. erythromycin, roxithromycin, clarithromycin, azithromycin)	151, 161
	mphB	E. coli, K. pneumoniae, S. enterica, E. fergusonii	14-, 15- and 16-membered macrolactones (e.g. erythromycin, roxithromycin, clarithromycin, azithromycin)	151, 161
	mphC	S. aureus	Erythromycin, roxithromycin, clarithromycin, azithromycin, oleandomycin	151, 161, 162