MIC90 of compounds against Mtb H37Rv.
| Compd | MIC90a (μg mL−1) | MIC90a (μM) | cLog Pb |
|---|---|---|---|
| 11a | 4.3 | 12.3 | 3.32 |
| 11b | 6.0 | 16.5 | 3.72 |
| 11c | 12.0 | 33.2 | 3.66 |
| 11d | 5.0 | 13.3 | 4.06 |
| 11e | 6.0 | 15.9 | 4.15 |
| 11f | 4.0 | 10.1 | 4.55 |
| 11g | 4.3 | 11.4 | 3.98 |
| 11h | 6.0 | 15.3 | 4.38 |
| 12a | 12.8 | 36.7 | 2.83 |
| 12b | 4.4 | 11.9 | 3.23 |
| 12c | 25.6 | 70.5 | 3.17 |
| 12d | 6.4 | 16.8 | 3.57 |
| 12e | 20.9 | 55.5 | 3.65 |
| 12f | 6.4 | 16.2 | 4.05 |
| 12g | 20.9 | 55.5 | 3.49 |
| 12h | 25.6 | 65.1 | 3.89 |
| Isoniazid | 0.2 | 1.8 | −0.64 |
| Kanamycin | 7.8 | 16.1 | −7.58 |
| Rifampicin | 0.2 | 0.3 | — |
a
Results are the average of two independent experiments.
b
Crippen's fragmentation.15