Molecular modeling of UOSO13 compared to fluconazole within the binding active site of C. albicans (PDB: 5V5Z).

Compound	Moiety	Interaction	Amino acid residue
UOSO13	NH	H-bond	Met-508
	Oxadiazole	Pi–pi stacking bond	Tyr-118
	Phenyl ring	Pi–pi stacking bond	Tyr-118
	tert-Butyl group	Hydrophobic interaction	Heme-601
	CH	Hydrophobic interaction	Leu-376 and Tyr-132
	Phenyl ring	Hydrophobic interaction	Pro-230 and Phe-233
Fluconazole	Triazole	Coordination bond	Heme-601
Native ligand	Phenyl ring	Pi–pi stacking bond	Tyr-118
	Triazole ring	Hydrophobic bond	Heme-601
	Phenyl ring	Hydrophobic bond	Leu-376, Phe-233, Pro-230, Tyr-132 and Tyr-118 and Phe-126
	Cl	Hydrophobic bond