Calculated binding energies of active oxadiazoles with 14 cytochrome P450 (14 α-sterol demethylase, CYP51).

Compound	Binding affinity (kcal mol−1)
	C. albicans CYP51 (PDB: 5FSA)	Human CYP34A (PDB: 4D7D)
UOSO10	−8.5	−5.9
UOSO12	−8.4	−5.4
UOSO13	−9.3	−4.9
UOSO14	−8.9	−5.3
Fluconazole	−6.7	−7.1