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. Author manuscript; available in PMC: 2023 Oct 28.
Published in final edited form as: Circ Res. 2022 Oct 13;131(10):e135–e150. doi: 10.1161/CIRCRESAHA.122.321384

Figure 7. Schematic illustration of the mechanisms underlying the immunomodulating effects of MSC-exosomes to induce Tregs for heart repair.

Figure 7.

Uptake of exosomes induced Foxo3 activation via modulating PP2A/p-Akt/Foxo3 pathway. Foxo3 promoted expression and secretion of IL-10, IL-33, IL-34 by MHC-II+ APCs to establish a Treg-inducing niche in the MLN. Following myocardial deployment, Tregs orchestrate inflammation resolution and cardiac reparation.