TABLE 4.
Theoretical Zadd (mg/kg), experimental Zmix (mg/kg), with CIs, and observed interactive effects of studied compound mixtures
| Combination | Zadd | Zmix | Interactive Effect |
| 1 Morphine: 1 Lofexidine | 9.13 (6.55–11.71) | 2.88 (1.94–3.81) | Supra-additive |
| 1 Morphine: 2 Lofexidine | 9.00 (6.45–11.54) | 1.42 (0.932–1.91) | Supra-additive |
| 3 Morphine: 1 Lofexidine | 9.22 (3.14–15.31) | 4.00 (2.23–6.23) | Additive |
| 2 Morphine: 1 Clonidine | 9.26 (6.64–11.84) | 2.90 (1.15–4.66) | Supra-additive |
| 1 Morphine: 2 Clonidine | 9.24 (6.63–11.86) | 1.57 (1.06–2.08) | Supra-additive |
| 3 Morphine: 1 Clonidine | 9.26 (6.65–11.88) | 5.73 (3.50–7.95) | Additive |
| 1 Methadone: 1 Lofexidine | 0.604 (0.541–0.668) | 0.514 (0.084–0.944) | Additive |
| 1 Methadone: 2 Lofexidine | 0.540 (0.159–0.922) | 0.237 (0.170–0.304) | Additive |
| 3 Methadone: 1 Lofexidine | 0.660 (0.279–1.04) | 0.767 (0.488–1.05) | Additive |
| 2 Methadone: 1 Clonidine | 0.683 (0.608–0.757) | 0.280 (0.137–0.424) | Supra-additive |
| 1 Methadone: 1 Clonidine | 0.672 (0.415–0.930) | 0.183 (0.0261–0.340) | Supra-additive |
| 4 Methadone: 1 Clonidine | 0.688 (0.590–0.786) | 0.680 (0.224–1.14) | Additive |
| 1 U69,593: 1 Lofexidine | 2.033 (1.71–2.35) | 1.01 (0.907–1.108) | Supra-additive |
| 1 U69,593: 2 Lofexidine | 1.91 (1.25–2.57) | 0.484 (0.395–0.573) | Supra-additive |
| 2 U69,593: 1 Lofexidine | 2.102 (1.73–2.47) | 1.23 (0.903–1.56) | Supra-additive |
| 2 U69,593: 1 Clonidine | 2.16 (1.82–2.50) | 0.735 (0.189–1.28) | Supra-additive |
| 1 U69,593: 2 Clonidine | 2.12 (1.73–2.51) | 0.567 (0.462–0.672) | Supra-additive |
| 3 U69,593: 1 Clonidine | 2.17 (1.82–2.51) | 1.63 (1.38–1.87) | Additive |